Interleukin‐1β activates a short STAT‐3 isoform in clonal insulin‐secreting cells
- 8 January 1999
- journal article
- Published by Wiley in FEBS Letters
- Vol. 442 (1) , 57-60
- https://doi.org/10.1016/s0014-5793(98)01623-8
Abstract
Interleukin-1β (IL-1β) is a potent inflammatory cytokine involved in type 1 diabetes and acts through defined IL-1β signaling pathways. In the present work we describe induction of DNA binding activity to signal transducer and activator of transcription (STAT) in response to IL-1β in clonal insulin-secreting cells. Moreover, IL-1β activates a short isoform of STAT-3 that potently stimulates transcription. Immunoprecipitation studies reveal an interaction between the activated STAT-3 and the IL-1 receptor accessory protein indicating an association between the two signaling pathways. This may be a novel point of transduction cross talk and an additional mechanism utilised by IL-1β in the pancreatic β-cell during the process of type 1 diabetes.Keywords
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