STUDIES ON POLYPEPTIDES

Abstract
A description is given of the synthesis by fragment condensation of 12‐(3‐Pyd) Ala** S‐peptide (1–14), the 1–14 peptide sequence of ribonuclease A in which the histidine‐12 residue is replaced by β‐(3‐pyridyl)‐L‐alanine. The peptide binds strongly and stoichiometrically to S‐protein; the resulting complex is enzymatically inactive.

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