In Vitro Lymphocyte Stimulation with Specific Antigen in Congenital Toxoplasmosis

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Abstract
The development of specific cell mediated immunity was studied in children with congenital toxoplasmosis; in vitro lymphocyte stimulation test (LST) was evaluated as a diagnostic test for congenital infection. The test was performed in 35 children, including 5 with a confirmed or suspected congenital toxoplasmosis and for comparison, in 19 dye test positive and 7 negative women. The development of delayed type hypersensitivity (DTH) seemed to follow approximately the same time course in children with congenital toxoplasmosis as in adults with toxoplasmosis. The lymphocyte responses to Toxoplasma antigen were low during the 1st yr, but increased markedly during the 2nd and 3rd yr after infection. Chemotherapy during the 1st yr of life did not prevent the later development of DTH. A positive LST during the 1st yr of life may be an indication of congenital toxoplasmosis. A negative test is not decisive.

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