Effect of stellate ganglion blockade on the hyperpnea of exercise.

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Abstract
Experiments were done in man to determine whether part of the hyperpnea of exercise might relate to sympathetic activation or alteration of carotid body chemore-ceptors. Four untrained young males exercised at 800 kg-m/min for 10-min warm up and control runs before and after bilateral blockade of the stellate ganglia with 1. 5 per cent lidocaine. Expired ventilation, end-tidal Pco2, and ECG [electrocardiogram] were continuously recorded, and arterial Pco2, PO2, and pH were determined twice before exercise, during the 4th and 9th min of exercise and the 3rd min of recovery. The average base excess at rest and during the 9th min of exercise before block was +1.2 and -2. 7, and after block was +1. 5 and -3. 3. There were no significant ventilatory changes in the control period, steady state, or recovery period before and after blockade. At the start of exercise, each subject showed a delay in the onset of hyperpnea after blockade.

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