Antineoplastic agents 300. Isolation and structure of the rare human cancer inhibitory macrocyclic lactones spongistatins 8 and 9
- 1 January 1994
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 13,p. 1605-1606
- https://doi.org/10.1039/c39940001605
Abstract
Two trace (0.7 and 2.2 × 10–7% yields) potent antineoplastic macrocyclic lactones termed spongistatins 8 (2a) and 9 (2b) have been isolated from the African marine sponge Spirastrella spinispirulifera and found to be very potent inhibitors of glutamate-induced tubulin polymerization.Keywords
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