Endothelin‐ and neuropeptide Y‐induced vasoconstriction of human epicardial coronary arteries in vitro
Open Access
- 19 July 1989
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 97 (3) , 968-972
- https://doi.org/10.1111/j.1476-5381.1989.tb12038.x
Abstract
1 The effects of the recently discovered peptide endothelin and neuropeptide Y (NPY) on human epicardial coronary arteries were studied in vitro. 2 Endothelin induced a concentration-dependent, endothelium-independent, long-lasting vasoconstriction regardless of vessel size. NPY evoked contractions of small coronary arteries with a similar potency to that of endothelin, although to a significantly lower degree. Large coronary arteries did not respond to NPY. Endothelin did not relax coronary arteries precontracted with potassium. 3 The effect of endothelin was dependent on extracellular Ca2+ and, like NPY, significantly reduced by the Ca2+-antagonist nifiedipine. 4 In conclusion, endothelin is a potent human vasoconstrictor in vitro. It is suggested that endothelin may be involved in the regulation of coronary blood flow.This publication has 22 references indexed in Scilit:
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