Detection of extended broad-spectrum beta-lactamases inEnterobacteriaceae in four French hospitals
- 1 June 1989
- journal article
- conference paper
- Published by Springer Nature in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 8 (6) , 527-529
- https://doi.org/10.1007/bf01967473
Abstract
In 210 strains ofEnterobacteriaceae which were isolated in four hospitals and which showed reduced susceptibility to cefotaxime, high synergy was demonstrated between amoxicillin (20µg) + clavulanate (10µg) and cefotaxime (30µg) using a simple double-disk test. Isoelectric focusing on gel and specific iodometric detection using ceftriaxone identified four extended broad-spectrumβ-lactamases (isoelectric points 7.6, 6.3, 7.0 and 5.9) produced by the strains.Keywords
This publication has 12 references indexed in Scilit:
- Plasmid-Mediated -Lactamase (TEM-7) Involved in Resistance to Ceftazidime and AztreonamClinical Infectious Diseases, 1988
- Novel plasmid-mediated beta-lactamase in clinical isolates of Klebsiella pneumoniae more resistant to ceftazidime than to other broad-spectrum cephalosporinsAntimicrobial Agents and Chemotherapy, 1988
- Synergy between clavulanic acid and newer β-lactams on nine clinical isolates of Klebsiella pneumoniae, Escherichia coli and Salmnella typhimurium resistant to third-generation cephalosporinsJournal of Antimicrobial Chemotherapy, 1988
- Dissemination of the novel plasmid-mediated beta-lactamase CTX-1, which confers resistance to broad-spectrum cephalosporins, and its inhibition by beta-lactamase inhibitorsAntimicrobial Agents and Chemotherapy, 1988
- Transferable resistance to third-generation cephalosporins in clinical isolates of Klebsiella pneumoniae: identification of CTX-1, a novel β-lactamaseJournal of Antimicrobial Chemotherapy, 1987
- TRANSFERABLE ENZYMATIC RESISTANCE TO THIRD-GENERATION CEPHALOSPORINS DURING NOSOCOMIAL OUTBREAK OF MULTIRESISTANT KLEBSIELLA PNEUMONIAEThe Lancet, 1987
- Novel R-factor borne β-lactamase of Escherichia coli confering resistance to cephalosporinsInfection, 1987
- Evolution of plasmid-coded resistance to broad-spectrum cephalosporinsAntimicrobial Agents and Chemotherapy, 1985
- Emergence of Resistance During Therapy with the Newer -Lactam Antibiotics: Role of Inducible -Lactamases and Implications for the FutureClinical Infectious Diseases, 1983
- Escherichia coli and Klebsiella pneumoniae strains more susceptible to cefoxitin than to third generation cephalosporinsJournal of Antimicrobial Chemotherapy, 1983