The Role of the Mast Cell in Anaphylaxis in the Mouse

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Abstract
Summary: Those organs showing the greater number of mast cells are not necessarily the ones showing the greater pathologic changes induced by anaphylaxis. Changes in mast cell number, morphology or products did not appear to be related to the anaphylactic phenomena. Serotonin and histamine, derived from sources other than the mast cell, are not likely to be the only mediating substances in mouse anaphylaxis. The formation of thrombi increased during anaphylaxis. Mice pretreated with anticoagulants show no significant differences in fatality from untreated mice, although treated animals had fewer thrombi. These thrombi are not antigen-antibody precipitates.

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