X-linked spastic paraplegia
- 1 June 1991
- journal article
- case report
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 83 (6) , 403-406
- https://doi.org/10.1111/j.1600-0404.1991.tb03972.x
Abstract
This paper describes a family with 10 males affected by x-linked spastic paraplegia. X-linked inheritance is rarely encountered in pure and complicated forms of hereditary spastic paraplegia. The disease was characterized by hyperreflexia, progressive spastic gait disorder, extensor plantar responses and mental retardation in all of the affected members of the family we studied. In addition to these symptoms, the older patients had cerebellar findings, severe disability and contractures. This is the 13th family manifesting x-linked spastic paraplegia reported in the literature.Keywords
This publication has 12 references indexed in Scilit:
- A familial syndrome of infantile optic atrophy, movement disorder, and spastic paraplegiaNeurology, 1989
- X‐linked spastic paraplegia: evidence for homogeneity with a variable phenotypeClinical Genetics, 1989
- Hereditary Spastic ParaplegiaJournal of Pediatric Orthopaedics, 1988
- The autosomal dominant form of “pure” familial spastic paraplegiaNeurology, 1987
- Linkage studies of X-linked recessive spastic paraplegia using DNA probesHuman Genetics, 1986
- Manifesting heterozygosity in sex-linked spastic paraplegia?Journal of Neurology, Neurosurgery & Psychiatry, 1984
- CLASSIFICATION OF THE HEREDITARY ATAXIAS AND PARAPLEGIASThe Lancet, 1983
- Hereditary "pure" spastic paraplegia: a clinical and genetic study of 22 families.Journal of Neurology, Neurosurgery & Psychiatry, 1981
- X-linked recessive type of pure spastic paraplegia in a large pedigree: absence of detectable linkage with Xg.Journal of Medical Genetics, 1976
- Strumpell's familial spastic paraplegia: genetics and neuropathologyJournal of Neurology, Neurosurgery & Psychiatry, 1974