Anabolic Action of Dianabol (17α-Methyl-17β-Hydroxyandrosta-1,4-Dien-3-One) on the Nitrogen Balance and Skeletal Muscle Composition of Rats Fed on Field Bean (Vicia Faba L.)

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Abstract
The addition of Dianabol (1 mg/100 g diet) to a diet containing raw field bean (V. faba) as the sole source of protein was studied in young male rats, fed for 2 wk on the legume diet, as compared to casein-fed animals. A significant improvement (P < 0.02) in the biological value and net protein utilization was found in the rats fed the legume diet with Dianabol added. A significant reduction (P < 0.02) in the non-protein nitrogenous fraction of the skeletal musculature, together with a significant rise (P < 0.02) in the sarcoplasmic and myofibrillar nitrogenous fractions of this musculature, was found in the rats fed the raw legume diet with Dianabol added. Serum insulin levels, significantly reduced (P < 0.02) in the legume-fed rats, reached the values of the control group by the addition of Dianabol to the legume diet. The possible nature of these effects is discussed.