Drug Diffusion: A Field Gradient Electron Paramagnetic Resonance Study

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Abstract
In order to gain information on the bioavailability of dermotherapeutics, field gradient electron paramagnetic resonance (FG EPR) spectroscopy was used. The characterisation of diffusion processes and distribution functions of different spin labeled molecules (Tempol, spin-labeled Lidocaine) within the ointment bases or skin is obtained by computer reconstruction of the spectra considering the diffusion concentration profiles derived from the model and comparison with the experimental FG EPR spectra. Results on the diffusion in some ingredients of ointment bases, emulsion gels and skin showed, that this method furnishes reliable data on molecular transport in these systems. The translational diffusion coefficients are larger for hydrophilic media than for hydrophobic ones, where a good correlation with the dynamic viscosity was found.

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