Thyroxine Pathways — Hypothesis

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Abstract
To the Editor: After reading Dr. Oppenheimer's discussion in the Seminars in Medicine of the Beth Israel Hospital (N Engl J Med 292:1063,1975), I am prompted to suggest that the answers to many seemingly complicated questions about thyroid disease might be clarified if a broader view of the hormone were considered. There is really no reason to think that an amino acid (thyroxine) would not exert at least some of its actions by amino acid mechanisms. There is, in fact, evidence that thyroxine, a tyrosine analogue, exerts many of its effects by entering all pathways of tyrosine metabolism.The most . . .