Fortnightly Review: A rational approach to the management of hepatitis C infection

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Abstract
Summary points The natural course of chronic hepatitis C is not fully defined A range of disease exists—from mild asymptomatic infection with few consequences to serious disease with dire sequelae Pretreatment assessments of viral load and genotype or serotype may help in predicting response It is difficult to indicate the prognosis for younger patients with mild disease; they may need to be considered for treatment, so that the opportunity to avoid later disease is not forfeited It is not yet clear whether patients who are more responsive to interferon have a better prognosis