Fluoride Directly Stimulates Proliferation and Alkaline Phosphatase Activity of Bone-Forming Cells
- 21 October 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 222 (4621) , 330-332
- https://doi.org/10.1126/science.6623079
Abstract
Fluoride is one of the most potent but least well understood stimulators of bone formation in vivo. Bone formation was shown to arise from direct effects on bone cells. Treatment with sodium fluoride increased proliferation and alkaline phosphatase activity of bone cells in vitro and increased bone formation in embryonic calvaria at concentrations that stimulate bone formation in vivo.This publication has 10 references indexed in Scilit:
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