Refined linkage mapping of a hip osteoarthritis susceptibility locus on chromosome 2q

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Abstract
Sir, Primary osteoarthritis (OA) is a common multifactorial genetic disease, with heritability estimates ranging from 30 to 70% depending upon the joint site affected [1]. Several genome‐wide linkage scans for OA susceptibility loci have been performed, with linkages reported to loci on chromosomes 2, 4, 6, 7, 11, 16 and the X [2–7]. Linkage of OA to chromosome 2q has been communicated in four independent studies: Wright et al. [2] reported linkage to markers mapping to 2q23–q35 in 66 nodal OA sibling pairs ascertained in the Nottingham region of the UK; Leppävuori et al. [6] reported linkage to 2q12–q21 in sibling pairs derived from 27 Finnish families that had a high prevalence of hand OA; our group reported linkage to 2q12–q31 in 311 UK sibling pairs concordant for hip OA [5]; finally, a group from the Netherlands have identified linkage of early‐onset, generalized OA to 2q24.3–q32.3 in several large Dutch pedigrees in which the OA segregates as a Mendelian trait (Ingrid Meulenbelt, personal communication). Overall, these studies indicate that chromosome 2q harbours an OA susceptibility locus.

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