CLINICAL CORRELATES OF THE TRH INFUSION TEST IN PRIMARY DEPRESSION

  • 1 January 1982
    • journal article
    • research article
    • Vol. 43  (5) , 191-194
Abstract
Relationships between clinical measures, diagnosis and neuroendocrine findings were examined in a group of 25 primary depressives maintained drug free on a neuropsychiatric evaluation unit. The TSH response to TRH infusion curves for unipolar and bipolar depressives were significantly different. Agitated patients, but not psychomotor retarded patients, demonstrated a blunted TSH response curve. No relationships were noted for cortisol hypersecretion and/or loss of diurnality, and either diagnosis or psychomotor activity levels, in depression. Biochemical and diagnostic implications of these findings are discussed.

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