An Algorithm for Comparing Two-Dimensional Electrophoretic Gels, with Particular Reference to the Study of Mutation

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Abstract
Concerns over the possible mutagenic effects of exposure to chemicals and radiation resulting from human activities, which surfaced so strongly in the 1950s, continue essentially unabated. Regulations and legislation in which genetic considerations play a significant role are being promulgated, and litigation concerning possible genetic damage from exposures resulting from human activities is in the courts. While animal models, particularly those employing the house mouse, have been essential in preliminary evaluations of the potential magnitude of the human risks, their potential for error in any precise evaluation of the magnitude of the issues is now apparent (Denniston, 1982; Kohn, 1983; Neel, 1983; Lyon, 1983). There is an urgent need for data on these risks derived from studies of human populations.