A Proton Nuclear-Magnetic-Resonance Study of Self-Stacking in Purine and Pyrimidine Nucleosides and Nucleotides
Open Access
- 1 July 1978
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 88 (1) , 149-154
- https://doi.org/10.1111/j.1432-1033.1978.tb12432.x
Abstract
The concentration dependence of the chemical shifts of the protons H-2, H-8 and H-1′ of ATP4− and of Mg(ATP)2−, of all non-labile protons of adenosine, of H-5, H-6 and H-1′ of UTP, and of H-5, H-6, H-1′, and H-2′ of uridine have been measured. The results for the purine derivatives are consistent with the isodesmic model of indefinite non-cooperative stacking; for adenosine K= 15 ± 2 M−1, for ATP K= 1.3 ± 0.2 M−1 and for Mg(ATP)2−K= 3.6 ± 0.3 M−1. For the pyrimidines, uridine and UTP, stacking is much weaker and the stability constant could only be estimated; for uridine K⋜ 0.5 M−1, and for UTP K≈ 0.3 M−1.This publication has 27 references indexed in Scilit:
- Hydrophobic Interactions between Metal Complexes of Aromatic Ligands and 3‐(Trimethylsilyl)‐1‐propanesulfonate and Their 1H‐NMR Spectroscopic DetectionAngewandte Chemie International Edition in English, 1976
- Intermolecular association in adenosine 5'-monophosphate. A deuterium nuclear magnetic resonance investigationJournal of the American Chemical Society, 1976
- Intermolecular orientations of adenosine‐5′‐monophosphate in aqueous solution as studied by fast fourier transform 1H nmr spectroscopyBiopolymers, 1974
- Nucleoside conformations: XIV. Conformation of adenosine monophosphates in aqueous solution by proton magnetic resonance spectroscopyBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1974
- Studies of inter- and intramolecular interaction in mononucleotides by proton magnetic resonanceJournal of the American Chemical Society, 1968
- Interaction and association of bases and nucleosides in aqueous solutions. V. Studies of the association of purine nucleosides by vapor pressure osmometry and by proton magnetic resonanceJournal of the American Chemical Society, 1967
- Association of adenosine-5′-phosphate in aqueous solutionsBiochemical and Biophysical Research Communications, 1967
- Interaction and Association of Bases and Nucleosides in Aqueous Solutions. IV. Proton Magnetic Resonance Studies of the Association of Pyrimidine Nucleosides and Their Interactions with Purine1bJournal of the American Chemical Society, 1965
- Hydrophobic Bonding. Its Detection by Nuclear Magnetic Resonance Spectroscopy and Its Effect on the Chemical Shifts of Internal StandardsJournal of the American Chemical Society, 1965
- Interaction and Association of Bases and Nucleosides in Aqueous SolutionsJournal of the American Chemical Society, 1963