Ceftizoxime compared with cefamandole for treatment of soft tissue infections

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Abstract
Acute skin and subcutaneous tissue infections in 64 adult patients were treated with ceftizoxime or cefamandole in a randomized study comparing the effectiveness of both drugs. Ceftizoxime (0.5–1.0 g twice daily) or cefamandole (0.5–1.0 g four times daily) was administered intravenously or intramuscularly for from 2 to longer than 7 days depending on response to treatment. Patients were evaluated clinically and bacteriologically for response to the drug and for drug safety. Both drugs provided effective antimicrobial therapy. Clinical response was good except in two elderly diabetic patients on cefamandole. Ceftizoxime at a dosage of 0.5–1.0 g twice daily proved to be as effective as cefamandole, 0.5–1.0 g administered four times daily. Both drugs were well tolerated; neither had to be discontinued because of adverse effects.

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