Pharmacology on rat ileum of certain 2-substituted 3-(dimethylamino)-5,6-dimethoxyindenes related to 5,6-(methylendioxy)indene calcium antagonist

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Abstract
Whereas the 2-propyl- and 2-butyl-5,6-(methylenedioxy)indene Ca antagonists reversed the spasmogenic action of several agonists including PG[prostaglandin]F2.alpha. and acetylcholine at 5 .times. 10-5 to 10-4 M on the rat ileum, the corresponding 5,6-dimethoxy analogs exhibited spasmogenic activity at higher concentration (10-4 to 10-3 M) and exhibited neither spasmogenic nor spasmolytic activity at lower (10-6 to 10-5 M) concentration. The results are compared to the methyl and 2-ethyl analogs. At 10-4 M only the butyl analog was capable of moderate antagonism of acetylcholine and at 10-3 M all 4 analogs were capable of moderately antagonizing the actions of acetylcholine.