Semisynthetic aminoglycoside antibacterials. Part 8. Synthesis of novel pentopyranosyl and pentofuranosyl derivatives of gentamine C1 and C1a

Abstract
The syntheses of a variety of 6-O- and 5-O-pentopyranosyl and -pentofuranosyl derivatives from 1,3,2′,6′-tetrakis-N-benzyloxycarbonylgentamine C1a and C1 are described. These include neutral glycosides as well as 3-amino-3-deoxy- and 3-deoxy-3-methylamino-glycosides. The solution conformations of these novel semisynthetic aminoglycoside antibacterials are described.

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