Chemical and Bioactive Constituents from Zanthoxylum simulans
- 1 September 1994
- journal article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 57 (9) , 1206-1211
- https://doi.org/10.1021/np50111a003
Abstract
Two new benzo[c]phenanthridine alkaloids, 6-methyldihydrochelerythrine [1] and 6-methylnorchelerythrine [2], together with 23 known compounds, were isolated from the root bark of Zanthoxylum simulans. Structures were elucidated by spectral analysis. Among them, the pyranoquinoline alkaloids, zanthosimuline [3], and huajiaosimuline [4], exhibited cytotoxic activity. In addition, compound 4 showed significant antiplatelet aggregation activity and induced terminal differentiation with cultured HL-60 cells.Keywords
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