INFLUENCE OF CHLOROPHYLL ON THE ACTIVITY OF GONADOTROPIC EXTRACTS TESTED ON NORMAL AND HYPOPHYSECTOMIZED IMMATURE FEMALE RATS1

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Abstract
A difference in the effect of a uniform amt. of chlorophyll on the activity of gonadotrophic extracts from varied sources is demonstrated. Doses of the extracts were chosen which would produce relatively the same increase in the ovarian wt. in immature rats. By the addition of chlorophyll, ant. pituitary extracts were augmented slightly, a [male] urine extract was not affected and mare serum hormone was completely inhibited. The degree of inhibition of the gonadotrophic activity of mare serum hormone varied with the amt. of chlorophyll added, the time when the chlorophyll was added and the period during which the chlorophyll and mare serum hormone were allowed to stand before inj. Addition of inert materials reduced the inhibiting power of chlorophyll on the gonadotrophic activity of mare serum hormone. The normal and hypophysectomized animal responded in virtually the same manner to mare serum and chlorophyll.