A CONTROLLED STUDY OF A TETRACYCLIC ANTIDEPRESSANTMAPROTIUNE (LUDIOMIL)

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Abstract
Maprotiline (Ludiomil) is a dlbenzo bicyclo octadiene, pharmacologically related to the tricyclic antidepressants and stereochemically haVing a tetracyclic structure. A controlled, doubl“e‐blind comparison of maprotiline and imipramine in a group of 71 female outpatients with primary depression is presented. Maprotiline was found to be at least as effective as imipramine and significantly better in depressive neurosis. It also showed a bipolar action, being effective in both agitation and retardation.

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