A COMPARATIVE CLINICAL-TRIAL OF THE CONTRACEPTIVE SPONGE AND NEO SAMPOON TABLETS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 65  (4) , 511-515
Abstract
Neo Sampoon, a foaming vaginal tablet containing 60 mg of the spermicide menfegol and the Collatex sponge (now marketed in the USA as the Today sponge), a dome-shaped polyurethane device that contains 1 g of nonoxynol-9, were compared in terms of effectiveness, safety, and acceptability. Both methods were new to the Maribor General Hospital, Yugoslavia, where the trial was conducted among 450 volunteers randomly assigned to 1 of the 2 methods. At 12 mo., the life-table pregnancy rate per 100 women for the Neo Sampoon group was 12.8, comapred with a rate of 10.4 among the sponge users (P < 0.10). After pregnancy, the 2nd most frequent reason for termination was discomfort, with a 12-mo. termination rate due to this cause of 6.9 per 100 women in the Neo Sampoon group and 6.2 in the sponge group. Although fewer than a quarter of the volunteers had any experience with barrier methods before this trial, the life-table continuation rate was high in both groups, with > 70% using their assigned method for the full 12 mo. Also, upon conclusion of the study, 41% of the volunteers chose another barrier contraceptive method. Although the effectiveness of the sponge and Neo Sampoon is not comparable to that of the pill or IUD [intrauterine device] both vaginal methods appear to be safe and acceptable additions to the range of contraceptive choices.

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