Merkel cells do not require trophic maintenance from the nerves in adult human skin
- 1 October 1995
- journal article
- case report
- Published by Wiley in British Journal of Dermatology
- Vol. 133 (4) , 553-556
- https://doi.org/10.1111/j.1365-2133.1995.tb02703.x
Abstract
A 34-year-old Japanese man with hereditary sensory neuropathy was examined to evaluate the distribution, density and inter-relationship between Merkel cells and peripheral nerves in the skin. An epidermal sheet of affected plantar skin showed numerous CAM 5.2-reactive Merkel cells, whereas PGP 9.5-reactive peripheral nerves were completely absent in the epidermis and dermis. These findings strongly suggest that Merkel cells do not require trophic maintenance from nerves in adult human skin.Keywords
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