Tissue Distribution of Primaquine in the Rat

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Abstract
The distribution of primaquine was measured in 7 rat tissues at 15-180 min after the i.p. injection of the antimalarial 8-aminoquinoline. The half-life of unmetabolized primaquine was 4.0 h in lung, 1.7-1.9 h in blood, spleen, kidney and heart and 1.2 h in liver. At each interval, the concentrations of unmetabolized primaquine were (in order) lung > liver, kidney, spleen > heart > brain .gtoreq. blood. At 3 h after the injection of [6-O-methyl-3H]primaquine, unmetabolized primaquine constituted 10% of the total 3H in blood and 40-60% of the total 3H in liver, brain, heart and kidney.

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