Emulsification Methods for Perfluorochemicals

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Abstract
A comparison of emulsification methods for novel perfluorochemical (PFC) emulsions for biological uses related to oxygen transport has been made. The emulsions were based on perfluorodecalin (FDC) and contained small quantities of polycyclic, perfluorinated, higher boiling point oil (HBPO) additives to stabilise against the process of molecular diffusion known as Ostwald ripening. Emulsification methods studied include sonication and homogenization which produced emulsions having similar particle size distributions. However, sonication generated fluoride (F-) ions which may have adverse physiological effects.