Effect of 17-Ketosteroids on Glucose-6-phosphate Dehydrogenase Activity (G6PD) and on G6PD Isoenzymes

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Abstract
In vitro experiments with rat hepatic glucose-6-phosphate dehydrogenase have shown that the activity of this enzyme is significantly inhibited by dehydroepiandro-sterone, androstenedione, androsterone and etiocholanolone at concentrations of 10-4 and 5×10-4 M. At these concentrations, dehydroepiandrosterone has specific inhibitory effects on glucose-6-phosphate dehydrogenase isoenzymes separated by acrylamide gel electrophoresis.