Amyloid Deposition in a Renal Transplant in Familial Mediterranean Fever

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Abstract
A patient with familial Mediterranean fever and amyloidosis who received a cadaver renal transplant 6 1/2 yr ago was studied to determine the relation of the serum precursor of secondary amyloid (SAA) to the clinical course and to the deposition of amyloid in the transplant. Amyloid fibrils extracted from the patient''s kidneys contained protein AA as a major constituent, which identified the amyloid as secondary. Protein AA antiserum was used in an indirect immunofluorescent technique to stain amyloid deposits in sections of the original kidney. A renal biopsy at 2 yr showed no amyloid, but a renal biopsy at 4 yr showed amyloid. Serum levels of SAA from 3 yr before transplant to 6 yr after transplant were elevated throughout most of the course.

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