SUBCLINICAL ADENOMAS OF THE HUMAN PITUITARY - NEW LIGHT ON OLD PROBLEMS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 107  (9) , 488-491
Abstract
Adenomas [107], found incidentally at autopsy in 100 pituitaries, were studied by histologic and immunohistochemical techniques to elucidate their cellular composition and hormone content. No adenohypophyseal hormones were found in 54 (50%) of the adenomas, whereas prolactin was shown in 45 (42%). Of the remaining tumors, 2 contained prolactin and growth hormone, 4 contained ACTH, 1 contained TSH and 1 contained luteinizing hormone. All adenohypophyseal cell types apparently can give rise to neoplasms. No correlation was found between clinical history, autopsy findings, or cause of death and the presence or type of adenoma. The adenomas caused neither local symptoms nor endocrine abnormalities. The prevalence of various adenoma types differed between autopsy specimens and surgical material.

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