The effect of ouabain, insulin, and cyclic AMP on the acidification of luminal fluid in the proximal tubule of bullfrog kidney.
Open Access
- 1 January 1988
- journal article
- research article
- Published by Physiological Society of Japan in The Japanese Journal of Physiology
- Vol. 38 (4) , 549-556
- https://doi.org/10.2170/jjphysiol.38.549
Abstract
A transient urinary acidification was induced in the bullfrog proximal tubule by the peritubular administration of ouabain (10-4M). Insulin (200mIU/ml) provoked a prolonged decrease of tubular fluid pH (TFpH), whereas dibutyryl cyclic AMP (10-4M) produced a transient increase of TFpH. The above data support the view that the urinary acidification in the proximal tubule is not explained by a simple mechanism, such as Na+/H+ exchange.Keywords
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