Peripheral Vascular Collapse after the Subcutaneous Use of a Hypertonic Nonelectrolyte Solution

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Abstract
IT has been shown experimentally in human beings that 5 per cent and 10 per cent dextrose in distilled water given subcutaneously will produce a state of mild peripheral vascular collapse.1 Danowski, Winkler and Peters2 have commented on an unpublished experiment in which an infusion of 5 per cent glucose in distilled water given subcutaneously had "effects on the plasma volume and circulatory dynamics identical with those of salt depletion shock." A recent editorial3 reviewed these experimental observations, and warned of "the possible dangers that might be encountered when large volumes of sugar containing, or amino acid containing solutions are . . .