Cervical Epidermal Growth Factor‐Receptor (EGF‐R) and Serum Insulin‐Like Growth Factor II (IGF‐II) Levels are Potential Markers for Cervical Cancer1

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Abstract
PROBLEM: To ascertain if cervical epithelial epidermal growth factor receptor (EGF‐R) and serum insulin‐like growth factor II (IGF‐II) levels are potential markers for cervical cancer. METHOD OF STUDY: We tested cervical biopsies obtained from 18 controls, 3 women with cervical intraepithelial neoplasia (CIN) I, 17 women with CIN II and III, and 12 women with cervical cancer for EGF‐R using a quantitative immunofluorescent antibody assay. We measured serum IGF‐II levels using an enzyme‐linked immunosorbent assay in 20 controls, 26 CIN patients, 12 with cervical cancer before therapy, 5 with cervical cancer for PPPP=0.03) had elevated levels of serum IGF‐II, while the women with CIN I had levels similar to controls. Women with cervical cancer in the post‐therapy period had significantly lower serum IGF‐II levels than the women with cervical cancer before therapy (P<0.001). CONCLUSION: Cervical epithelial EGF‐R and serum IGF‐II levels may be used for the diagnosis and prognosis of cervical cancer.

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