What's new: Conditional cell ablation in Drosophila
- 1 July 1993
- Vol. 15 (7) , 491-493
- https://doi.org/10.1002/bies.950150710
Abstract
Targeting of cell ablation agents under the control of tissue‐specific promoters promises to be an important tool for studies of development and function in higher organisms. Temperature‐sensitive cell ablation agents, recently developed for Drosophila, extend control to temporal as well as spatial aspects of toxin expression. Here we discuss achievements to date, together with a novel form of enhancer trap technology with the potential for driving toxin expression in a large range of cell types.Keywords
This publication has 15 references indexed in Scilit:
- Ablation of Drosophila photoreceptor cells by conditional expression of a toxin gene.Genes & Development, 1991
- Reprogramming cell fate in the developing Drosophila retina: transformation of R7 cells by ectopic expression of rough.Genes & Development, 1990
- Regulation of the complex pattern of sevenless expression in the developing Drosophila eye.Proceedings of the National Academy of Sciences, 1989
- Dissecting mouse development with toxigenics.Genes & Development, 1989
- Lens-specific expression of recombinant ricin induces developmental defects in the eyes of transgenic mice.Genes & Development, 1988
- GAL4 activates transcription in DrosophilaNature, 1988
- Cell lineage ablation in transgenic mice by cell-specific expression of a toxin geneCell, 1987
- Isolation and structure of a rhodopsin gene from D. melanogasterCell, 1985
- Neuronal development in the drosophila retina: Monoclonal antibodies as molecular probesCell, 1984
- Diphtheria ToxinAnnual Review of Biochemistry, 1977