In vitro directed differentiation of mouse embryonic stem cells into insulin-producing cells
Open Access
- 29 July 2004
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 47 (8) , 1442-1451
- https://doi.org/10.1007/s00125-004-1458-8
Abstract
We recently demonstrated that insulin-producing cells derived from embryonic stem cells normalise hyperglycaemia in transplanted diabetic mice. The differentiation and selection procedure, however, was successful in less than 5% of the assays performed. Thus, to improve its effectiveness, new strategies have been developed, which increase the number of islet cells or islet progenitors.Keywords
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