Incidence of cardiac septal defects in children with Wilms' tumour and other malignant diseases
- 1 January 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 8 (1) , 129-132
- https://doi.org/10.1093/carcin/8.1.129
Abstract
In a population-based series of 8045 children with malignant neoplasms in Great Britain, the incidence of septal defects was 0.40%. The high rate of 19% in Down's syndrome dill dren and the overall rate of 0.28% in children without Down's syndrome were both comparable with rates found in previous large prospective studies. The incidence of septal defects in children with Wilms' tumour was 1.82%, >10 times that for non-Down's children with other neoplasms. The presence of this association in Wilms' tumour patients with and without aniridia and the recent finding of a loss of heterozygoslty in chromosome 11 in many Wihms' tumours taken from patients without aniridia suggest the possibility of a link between Wihms' tumour, some septal defects and chromosomal abnormalities.This publication has 5 references indexed in Scilit:
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