HEMOGLOBIN HOPE - STUDIES OF OXYGEN EQUILIBRIUM IN HETEROZYGOTES, HEMOGLOBIN S-HOPE DISEASE, AND ISOLATED HEMOGLOBIN HOPE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 88  (1) , 125-131
Abstract
Hb Hope (.beta.(H14)136gly .fwdarw. asp), a mildly unstable variant, had decreased O2 affinity, a normal Bohr effect and diminished cooperativity. Decreased O2 affinity of Hb Hope may explain the previous failure to find an appropriate response to hemolysis in individuals studied who were heterozygous for both Hb Hope and sickle Hb. Salt bridge formation between NA1 valine and H14 aspartic acid may stabilize the .beta.Hope subunit in its deoxy form, producing intrinsically low O2 affinity and reduced cooperativity.

This publication has 2 references indexed in Scilit: