Cloning of nocardioform DNA conferring the ability to inactivate rifampicin
- 15 April 1991
- journal article
- Published by Oxford University Press (OUP) in FEMS Microbiology Letters
- Vol. 79 (2-3) , 247-250
- https://doi.org/10.1016/0378-1097(91)90093-p
Abstract
A novel mechanism of resistance to rifampicin has recently been reported in which this antibiotic is inactivated. Here we describe the cloning of DNA from a nocardioform strain conferring this ability to inactivate rifampicin. Cloning was on the basis of complementation, as an increased resistance to the antibiotic. The genetic information was on a 8.3-kb BglII fragment.Keywords
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