The Peripheral Platelet Count in Response to Intravenous Infusion of Salbutamol

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Abstract
Five healthy male volunteers received i.v. infusions of salbutamol, a relatively selective .beta.-2-receptor-stimulating agent, in doses of 0.03, 0.06, 0.09 and 0.27 .mu.g/kg-1 per min-1 over a period of 6 min. At the 3 low doses the heart rate remained essentially unchanged and no significant decrease in the platelet count occurred. However, in response to 0.27 .mu.g/kg-1 per min-1 of salbutamol the heart rate increased by 25% over basal value (P < 0.01) and a significant lowering (P < 0.005) of the platelet count was obtained. The drop in the peripheral platelet concentration in response to adrenergic .beta.-receptor stimulation appears to be mediated via .beta.-1-receptors.

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