COMPARATIVE ANTISECRETORY ACTIVITY OF SEVERAL DRUGS IN GASTRIC FISTULA SQUIRREL-MONKEY AND RAT

  • 1 January 1977
    • journal article
    • research article
    • Vol. 17  (3) , 365-373
Abstract
A series of known antisecretory compounds, including glycopyrrolate, clonidine, propantheline bromide, CMN 131 (2-pyridylthioacetamide) and desmethylimipramine (DMI) were tested in the gastric fistula rat and monkey [Saimiri sciureus]. The order of potency for inhibiting acid output was similar in both species. A general similarity exists in the responsiveness of the rat and monkey to gastric antisecretory agents. The use of the squirrel monkey for assessment of gastric antisecretory activity is supported.

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