EFFECTS OF ACIDOSIS ON THE ACTIVITY OF CREATINE-PHOSPHOKINASE AND ITS ISOENZYMES IN THE SERUM OF NEWBORN-INFANTS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 68  (2) , 195-197
Abstract
The total creatine phosphokinase (CPK) activity and the levels of activity of its MM, MB and BB isoenzymes were measured in sera obtained within 4 after birth from 32 newborn [human] infants. The total CPK level and activity of its MM, MB and BB isoenzymes increased significantly with increasing acidosis. Statistically significant correlations were also found between the total CPK level in infants'' sera and their 1 min Apgar scores. The infants'' birth weight, gestational age and mode of delivery did not correlate significantly with the serum total CPK activity. Infants who died within 10 days after birth from causes related to asphyxia had significantly higher total CPK activity levels in their sera compared to survivors. Perinatal asphyxia with acidosis may result in leakage of CPK and its isoenzymes from the damaged cells into the circulation; a marked elevation of their values may indicate a poor prognosis for survival.

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