Release of Neurotransmitter Amino Acids from Rat Brain Synaptosomes and Its Regulation in Aging
- 1 January 1988
- journal article
- neurohumoral mechanisms-of-aging
- Published by S. Karger AG in Gerontology
- Vol. 34 (1-2) , 35-40
- https://doi.org/10.1159/000212928
Abstract
The release of neurotransmitter amino acids 14C-Asp, 14C-Glu and 14C-GABA from rat brain synaptosomes in aging is studied. It is established that K+-induced Ca2+-dependent and Ca2+-independent release of these amino acids decreases significantly in the old animals. K+ (40 mM) stimulates strongly their release for both ages, but the effect of K+ ions in old animals is less marked. Removal of Ca2+ has a greatly inhibitory effect on synaptosomal release in young as well as in old rats. The degree of inhibition does not depend on age, though it takes place at a lower level in old rats.Keywords
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