Isolation and structure of rolliniastatin 1 from the South American tree Rolliniamucosa
- 1 June 1987
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 65 (6) , 1433-1435
- https://doi.org/10.1139/v87-242
Abstract
Rollinia mucosa (Annonaceae), known in primitive medical practices of Indonesia and the West Indies as a treatment for tumors, has been investigated employing the seeds from a South American variety and the murine P388 lymphocytic leukemia (PS) for bioassay. The principal antineoplastic constituent (PS, 28% life extension, at 0.25 mg/kg and ED50 4.5 .times. 10-5 .mu.g/mL) was found to be a new bis-tetrahydrofuran designated rolliniastatin 1. Structural elucidation of rolliniastatin 1 was accomplished by a combination of high resolution nuclear magnetic resonance (300 MHz), mass spectral, and X-ray crystal structure techniques.This publication has 4 references indexed in Scilit:
- Isolation, Structure, and Synthesis of Combretastatins A-1 and B-1, Potent New Inhibitors of Microtubule Assembly, Derived from Combretum caffrumJournal of Natural Products, 1987
- Biosynthetic Product Molecular Weight Determinations by Solution Phase Secondary Ion Mass Spectrometry Employing Group 1A Metal SaltsJournal of Natural Products, 1985
- Rollinicin and isorollinicin, cytotoxic acetogenins from Rollinia papilionellaPhytochemistry, 1984
- Rollinone, a New Cytotoxic Acetogenin from Rollinia papilionellaJournal of Natural Products, 1984