INTRAPERITONEAL HYPERTHERMIC TREATMENT OF IMPLANTED PERITONEAL CANCER IN RATS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (11) , 4081-4084
Abstract
The feasibility and efficacy of treating peritoneal cancer implants by applying heat to the peritoneal surfaces were studied in inbred Buffalo A rats given i.p. injections of Morris hepatoma 5123TC tumor cells. Heat was delivered to the peritoneum by contact with a heated physiological salt solution (Normosol-R) in the peritoneal cavity. A treatment temperature of 43.3 .+-. 0.3.degree. C was maintained for 30 min by an immersed stainless steel through which hot liquid circulated. Rats implanted with 0.5-1.0 .times. 108 tumor cells were treated at 1-4 h (group I), 4-5 days (group II) and 22-24 days (group III) after tumor implantation to simulate treatment for the clinical conditions of surgically spilled cancer cells, established microscopic cancer implants and macrosopic cancer implants, respectively. A statistically significant improvement in survival was observed in groups I and II compared with sham-treated control animals; 58% of the heat-treated animals were cured. Only a slight but statistically insignificant improvement was noted in group III. These observations indicate that i.p. surface heat treatment of peritoneal implanted cancer is feasible and effective.

This publication has 0 references indexed in Scilit: