Use of Infrared Attenuated Total Reflectance Spectroscopy for the in vivo Measurement of Hydration Level and Silicone Distribution in the Stratum corneum following Skin Coverage by Polymeric Dressings
- 2 June 2000
- journal article
- clinical trial
- Published by S. Karger AG in Skin Pharmacology and Physiology
- Vol. 13 (3-4) , 157-164
- https://doi.org/10.1159/000029921
Abstract
The ability of wound dressings to hydrate the stratum corneum has been tested experimentally using attenuated total reflectance (ATR) infrared spectroscopy. A silicone gel dressing was able to hydrate the stratum corneum to the extent that its water content within the sampled volume was >60% after 5 h of contact compared with about 15% of normal exposed skin and about 30% for a highly permeable hydrophilic polyurethane dressing. An ATR method was devised to determine the presence and depth of penetration of silicone in the stratum corneum as a result of skin coverage by the polymeric dressing.Keywords
This publication has 2 references indexed in Scilit:
- Water Diffusion Characteristics of Human Stratum Corneum at Different Anatomical Sites In VivoJournal of Investigative Dermatology, 1998
- Functional analyses of the stratum corneum in scars. Sequential studies after injury and comparison among keloids, hypertrophic scars, and atrophic scarsArchives of Dermatology, 1996