Neurovisceral Glucocerebroside Storage (Gaucher's Disease) in a Dog

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Abstract
An 8-month-old Sydney Silky dog that was ataxic and hyperkinetic was found to have a neurovisceral storage disease. Typical Gaucher cells were seen in the liver, lymph nodes and cerebellum, but not in the spleen. Ultrastructurally, the storage bodies in Gaucher cells contained tubular structures, and many neurones contained laminated cytosomes. accumulations of a ‘wispy’ material and rarely tubular material. Chemically, the liver and brain contained glucocerebroside.

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