Fixed Drug Eruption of the Penis Due to Hydroxyzine Hydrochloride
- 1 March 1997
- journal article
- case report
- Published by SAGE Publications in Annals of Pharmacotherapy
- Vol. 31 (3) , 327-329
- https://doi.org/10.1177/106002809703100311
Abstract
Objective: To report four cases of fixed drug eruption induced by hydroxyzine hydrochloride (Otarex, Teva, Israel). Case Summary: Four children with restlessness who were treated with hydroxyzine hydrochloride developed fixed drug eruption of the penis. Drug discontinuation was followed by complete resolution of the skin eruption. Rechallenge resulted in the same drug rash. Macrophage migration inhibiting factor (MIF) assay with hydroxyzine hydrochloride was positive. Discussion: The pathogenesis of fixed drug eruption and the role of macrophage MTF assay in diagnosis is discussed. Conclusions: A fixed drug eruption induced by hydroxyzine hydrochloride is possible, but is a rare phenomenon.Keywords
This publication has 6 references indexed in Scilit:
- Paracetamol-induced fixed drug eruption with positive immunofluorescence findingsClinical and Experimental Dermatology, 1990
- Fixed Drug Eruption of the Penis Due to Co-TrimoxazoleDrug Intelligence & Clinical Pharmacy, 1987
- Fixed Drug EruptionArchives of Dermatology, 1984
- DEMONSTRATION OF INTERCELLULAR IMMUNOFLUORESCENCE AND EPIDERMAL HYSTERESIS IN BULLOUS FIXED DRUG ERUPTION DUE TO PHENOLPHTHALEINBritish Journal of Dermatology, 1972
- CURRENT CAUSES OF FIXED DRUG ERUPTIONSBritish Journal of Dermatology, 1970