Posterior Urethral Valves, Unilateral Reflux and Renal Dysplasia: A Syndrome

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Abstract
Infants with posterior urethral valves and persistent unilateral reflux were valve resection often have an associated nonfunctioning, dysplastic kidney. Spurious function of the unit with reflux may be apparent on the delayed films of the excretory urogram. Misinterpretation of the initial radiographic studies performed without coincident bladder drainage results in the missed diagnosis of this syndrome and misguided surgical management. Of 82 patients with urethral valves 17 (21%) had persistent unilateral reflux. A renal scan was useful in determining nonfunction in 11 (65%) of those patients with persistent unilateral reflux and 1 with bilateral reflux. The functionless kidney was on the left side in 11 of 12 cases (92%). Early nephroureterectomy is advocated to improve voiding dynamics. The prognosis is generally excellent. The embryogenesis of the syndrome is discussed as it relates to the bud theory of renal dysplasia and posterior urethral valves.