Isolation of a bromo analog of rebeccamycin from Saccharothrix aerocolonigenes.
- 1 January 1991
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 44 (9) , 934-939
- https://doi.org/10.7164/antibiotics.44.934
Abstract
When grown in a defined medium containing 0.05% KBr, Saccharothrix aerocolonigenes ATCC 39243 produces a novel bromo analog of rebeccamycin. This new analog, designated bromorebeccamycin, has been isolated from the culture broth and purified by vacuum liquid chromatography and column chromatography. Spectroscopic data demonstrated that bromorebeccamycin has the same structure as rebeccamycin, except for the replacement of the two chlorine atoms by bromine atoms in the molecule. Bromorebeccamycin and rebeccamycin have a similar potency and activity against P388 leukemia in the murine model.Keywords
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